4. What are the consequences of toxic liver damage?
Toxic liver damage is characterized by a sharp increase in liver biomarkers in the blood:
isolated or predominant increase in transaminases, particularly ASpartate-AminoTransferase (ASAT);
increased alkaline phosphatase ;
isolated increase in Gamma-GlutamylTransferase (GGT).
Liver damage also leads to structural changes in the liver, visible on histological examination.
4.1 Acute exposure to ethanol
This exhibition leads to :
an accumulation of lipids in the cells (steatosis);
hepatic necrosis;
...
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What are the consequences of toxic liver damage?
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Bibliography
B. Mégarbane, N. Deye, F. Baud: Foie toxique: lésionnels et thérapeutiques, pharmacologiques spécifiques, Réanimation 16, 632-642 (2007).
Lombard et al (2024), part 2 pp. 153-281, Évaluation technico-économique des produits au stade initial du développement, ISTE éditions, Ltd London.
Acronyms/abbreviations
ASAT: ASpartate-AminoTransferase (ASAT)
ALAT: ALanine amino transferase
GGT: Gamma-GlutamylTransferase
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