3. Pharmaceutical and biomedical applications
As the "positive" list of GRAS (Generally Recognized As Safe) solvents is constantly shrinking, there is keen interest in using supercritical CO 2 as a solvent for extraction, fractionation and, above all, formulation of pharmaceutical and dermocosmetic active ingredients.
First of all, when products for the pharmaceutical industry are produced, the equipment must be designed, operated, cleaned and maintained in accordance with strict standards for the protection of operators, the environment and the final product (GMP).
Note: Good Manufacturing Practice (GMP).
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Extraction
Apart from the extraction of naturally-occurring active ingredients (cf. § 1.), known industrial applications are...
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Pharmaceutical and biomedical applications
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Bibliography
Reference works
Thousands of articles, patents and symposium proceedings ( http://www.isasf.net ), dozens of books make up a considerable bibliography. See The Journal of Supercritical Fluids (Elsevier). Here are a few reference works and bibliographical reviews:
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