Therapeutic target identification and validation: with cells
Microfluidics, a versatile tool in healthcare
Article REF: PHA1030 V1
Therapeutic target identification and validation: with cells
Microfluidics, a versatile tool in healthcare

Authors : Jérémie GOUYON, Thibault ROQUES-CARMES, Anne SAPIN-MINET, Marianne PARENT

Publication date: October 10, 2024 | Lire en français

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2. Therapeutic target identification and validation: with cells

Microfluidics can be used to isolate cells (essentially in droplets or chambers), creating controllable three-dimensional (3D) microenvironments for their culture, or to present them with a molecule or another cell. The applications are numerous, whether for the development of vaccines, antibodies, anti-infectives or anti-cancer drugs.

2.1 Identification of new targets

Example:

With the ultimate aim of developing a vaccine against human immunodeficiency virus-1 (HIV-1), Chaipan et al. have developed a microfluidic droplet system for isolating one virus per drop and studying its ability to bind neutralizing antibodies

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