4. Basic laboratory data for solid-phase development

4.1 List of basic laboratory data

The development of a process to obtain a polymorphic variety or a non-solvated or solvated solid phase can only be envisaged if the system's thermodynamic and kinetic data are known. There are three main points to consider:

1. identify solid phases by screening ;

2. know the relative thermodynamic stability of the solid phases found (including polymorphic varieties and solvates);

3. understand transition kinetics from one phase to another.

In the pharmaceutical field, screening is essential for selecting the polymorph that will be developed industrially. In particular, it is important to find the most thermodynamically stable polymorph. If it meets bioavailability...