1. What are DMELs?
The establishment of DMELs is an important step in the overall process of assessing the hazards of a chemical substance. It is the logical continuation of studies that have been carried out to determine the ADME of this substance, as well as the results of short-, medium-, and long-term in vitro and in vivo toxicological studies.
1.1 Definition
Derived minimal effect levels (DMELs) are values that must be defined under the European REACH regulation for chemical substances whose effects on humans do not allow a threshold to be established.
These are reference values based on relative cancer risk, which are used to implement appropriate risk management measures for human populations, including workers.
A DMEL differs...
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What are DMELs?
How to establish a DMEL?
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