Practical sheet | REF: FIC1182 V1

Determining DNELs

Author: Alain LOMBARD

Publication date: February 10, 2015 | Lire en français

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2. How do you establish a DNEL?

Picto outil Tool

First of all, the toxicological profile of the substance must be established and all relevant data collected. The most relevant and valid studies should then be selected (Klimisch, see Criteria for determining the rating of a study (Tool Criteria for determining the rating of a study. Adapted from Klimisch et al (1997) and Rosner (1994) )).

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How do you establish a DNEL?