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Practical sheet | REF: FIC1182 V1

Determining DNELs

Author: Alain LOMBARD

Publication date: February 10, 2015, Review date: September 1, 2025 | Lire en français

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    1. What are DNELs?

    1.1 Definition

    Derived Non Effect Levels (DNELs) are the limit values to be set under the European REACh regulation for chemical substances whose threshold effects have been defined in toxicology studies. These are the exposure levels for a chemical substance below which human populations, including workers, should not be affected.

    Please note

    For non-threshold substances (genotoxic, carcinogenic), a semi-quantitative assessment (Derived Minimal Effect Level – DMEL) will be defined.

    In the absence of data, a qualitative assessment based on expertise will be used.

    (see Determination of DMELs

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