2. How do you establish a DNEL?
First of all, the toxicological profile of the substance must be established and all relevant data collected. The most relevant and valid studies should then be selected (Klimisch, see Criteria for determining the rating of a study (Tool Criteria for determining the rating of a study. Adapted from Klimisch et al (1997) and Rosner (1994) )).
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How do you establish a DNEL?
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