8. Glossary
QSAR
Qualitative Structure-Activity Relationship: The presence of specific hormone-like chemical structures in a chemical formulation may indicate a potential PE.
Cytochromes
Cytochromes are enzymes present in various tissues and involved in the metabolism of endogenous and exogenous substances, including many drugs.
Cytochrome P450
It's a complex system of iso-enzymes. Four iso-enzymes are involved in the metabolism of around 90% of commonly used drugs. These are generally referred to as CYP 1A2, CYP 2C9, CYP 2D6 and CYP 3A4. The iso-enzymes CYP 2B6, 2C8 and 2C19 are involved in only a few interactions.
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Bibliography
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Bibliography
Anses (2014a): Assessment of the health risks associated with the presence of endocrine-disrupting and/or reprotoxic substances in consumer products. Collective expertise report, Maisons-Alfort.
Anses (2014b): Caractérisation des dangers et des expositions liés à la présence de substances perturbatrices endocriniennes et/ou reprotoxiques dans les produits de consommation....
Regulations
Règlement (UE) 2020/878 de la Commission du 18 juin 2020 amending Annex II to Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH)....
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