2. What are endocrine disruptors (EDs)?
According to the WHO definition in 2012: "An endocrine disruptor is an exogenous substance or mixture that alters the functions of the endocrine system and thus induces adverse health effects in an intact organism, its progeny or subpopulations".
Endocrine disruptors act in three different ways.
Mimetic (or agonist) effect: imitation of the action of a natural hormone (like a false key in the "biological locks" that exist in organs and cells).
Blocking effect (or antagonist): blocking the action of a natural hormone (by saturating cell receptors, for example).
Disruptive (or interference) effect: disruption, i.e. hindrance or blockage of the production, transport or metabolism of hormones or receptors, induced by abnormal hormonal action in the body...
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What are endocrine disruptors (EDs)?
Bibliography
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Bibliography
Anses (2014a): Assessment of the health risks associated with the presence of endocrine-disrupting and/or reprotoxic substances in consumer products. Collective expertise report, Maisons-Alfort.
Anses (2014b): Caractérisation des dangers et des expositions liés à la présence de substances perturbatrices endocriniennes et/ou reprotoxiques dans les produits de consommation....
Regulations
Règlement (UE) 2020/878 de la Commission du 18 juin 2020 amending Annex II to Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH)....
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