Quality aspects of recombinant proteins
Production methods of recombinant proteins; towards mastering glycosylation
Article REF: BIO6200 V1
Quality aspects of recombinant proteins
Production methods of recombinant proteins; towards mastering glycosylation

Authors : Jean-Louis GOERGEN, Emmanuel GUEDON, Marie-Françoise CLINCKE

Publication date: May 10, 2011 | Lire en français

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2. Quality aspects of recombinant proteins

2.1 Post-translational changes

Posttranslational modifications (PTMs) include protein aggregation, methionine oxidation, deamination of asparagine and to a lesser extent glutamine, lipid addition, proteolysis, γ-carboxylation, glycosylation and protein sulfation .

Such modifications not only represent a challenge for the production...

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