Conclusion

The structural bioinformatics tools described in this article are a very useful support for the biologist aware of the importance of 3D structure in the functional elucidation of biological macromolecules. Most of them are available as web services or can be downloaded and installed for different operating systems, i.e. Linux, MacOs or Windows. Beyond their ease of use, it is essential to be aware of the limitations of the proposed methodologies by reading, of course, the reference publications, but also by taking note of the results of competitions organized regularly to evaluate the performance of these methods. The "CASP" (Critical Assessment of techniques for protein Structure Prediction) competition