6. From genome to interactome: the enzymatome as an example

As with every living thing that works with its fellow creatures and "friend or foe" species, molecules like enzymes don't act alone. All the points made above have been developed to demonstrate this. Enzyme proteins are by no means the only focus of studies based on the interactome.

Enzymes are at the heart of molecular complexes, which can be large or small, evolving and transient, and more or less difficult to understand depending on the case under study. Depending on the structure of the complex, enzyme activity is regulated differently. In these complexes, partners from the same genome or from foreign genomes may be involved: we can speak of specific "intra" or "inter" interactomes. While genetic variability within different species is taken into account, the full range of links between different partners is difficult to grasp. As our knowledge of genomics,...