1. Transfers, genetic recombination and viral and bacterial mutants

Whatever the strain of pathogenic micro-organism, it is always interesting to be able to specifically inhibit its enzymes, whether wild-type, mutated or recently acquired.

• A mutation is a stable, heritable change in the genome of a living organism. Every living individual has a characteristic nucleotide sequence. A mutation is a change in one or more nitrogenous base pairs of the nucleotide sequence concerned. The mutated gene is different from the wild-type gene, which is characterized by a different phenotype in the individual expressing the mutant protein derived from the gene. For example, for a mutated enzyme with a non-silencing mutation, the kinetic parameters k _cat , K _M , K _eff (respectively catalytic...