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Article | REF: PHA1504 V1

Molecular enzymology - Enzymatic catalysis

Authors: Julien DUMOND, Serge KIRKIACHARIAN

Publication date: April 10, 2025 | Lire en français

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    3. Activated human enzymes

    3.1 Ion activation

    Magnesium ions Mg 2+ are essential for the activity of kinases catalyzing phosphate group transfer. These enzymes are known as phosphotransferases. Under normal conditions, the Mg 2+ cation binds to ATP, and the kinases interact with the ATP coenzyme in the form ATP-Mg 2+ . This is an indirect activation.

    Calcium cations Ca 2+ are activators of certain peptidases (peptide catabolism).

    The chloride anions Cl – are activators of certain amylases (starch hydrolysis).

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