6. Conclusion
Rectal forms have been described since antiquity and are still used today. This "ancient" therapeutic form has gradually been abandoned by developed countries in favor of new oral forms deemed more effective and better accepted by patients. By the late 1990s, suppositories were considered to be on the wane. However, since the early 2000s, the scientific community has revived interest in suppositories.
The raw materials used to prepare suppositories are well known and limited, mainly fats such as hydrogenated vegetable oils and hemisynthetic glycerides, or hydrophilic polymers such as polyethylene glycols and gelatin. The very good cost-functionality ratio of these raw materials does not suggest the development of new chemical molecules for this application.
The molding process for suppositories is still the most widely used in the pharmaceutical...
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Conclusion
Bibliography
Websites
GATTEFOSSE, Hemisynthetic glycerides for suppositories and ovules with solid or liquid active ingredients, Internet http://www.gattefosse.com/fr/applications/?voie-d-administration,rectale-et-vaginale (page consultée le 11/06/2013)
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Norms and standards
- Classification biophamarceutique BCS - Pharmacopée Européenne 7.0 - . 2012
Patents
STEVENSON (W.G) and MACKINNON (W.E.) (5-2-1952) US Patent US 2,584,166, Deposited it 25-5-1948, Suppository.
SCHLUETER (K.W.) and SCHULTZ-KAISER (E.) (24-4-1979) US Patent US 4,151,274, Deposited it 15-11-1976, Process and composition for the production of suppositories.
GOYAN (J.E.) and WRABLE (M.) (14-3-1961) US Patent US 2,975,099, Deposited it 25-6-1958, Polyethylene glycol...
Directory
Manufacturers – Suppliers – Distributors (non-exhaustive list)
Dow for polyethylene glycols http://www.dow.com/polyglycols/polyethylene/products/carbowaxp.htm
Gattefossé for suppositories http://www.gattefosse.com/fr/applications/?voie-d-administration, rectal and vaginal masses
Cremer oleo for suppository masses http://www.cremeroleo.de/en/produktbereiche/cremer-health/index.php...
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