General characteristics of current LC-MS couplings
Coupling chromatography with mass spectrometry (Third part)

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P1492 V1 Article

General characteristics of current LC-MS couplings


Coupling chromatography with mass spectrometry (Third part)

Author : Patrick Arpino

Publication date: December 10, 2009 | Lire en français

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2. General characteristics of current LC-MS couplings

Two interface levels are used in all recent LC-MS systems. Interface 1 (see Chromatographic couplings with mass spectrometry I [P 1 490] , § 4.6, figure 7) comprises a nebulizer and a generator of ions from the solutes in the chromatographic eluent, based on different ionization methods APCI, APPI, ESI... and mounted on an atmospheric pressure chamber (API). Interface 2 combines, in line, a sampling zone towards the vacuum and an ion guidance optic towards the mass spectrometer analyzer. This analyzer is more or less complex and powerful, depending on the instrument model, and is...

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