Solvent classification and selection
Liquid chromatography - Separation theory and methods
Article REF: P1455 V2
Solvent classification and selection
Liquid chromatography - Separation theory and methods

Authors : Marcel CAUDE, Alain JARDY

Publication date: October 10, 1994, Review date: February 5, 2019 | Lire en français

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3. Solvent classification and selection

3.1 Solvent properties

Successful separation depends on the solute-stationary phase-mobile phase match.

In principle, a wide range of solvents (usually in mixtures) can be used, but there are many limitations.

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3.1.1 Solute-solvent interactions

Three groups of interactions can be distinguished. The first includes intermolecular forces of dispersion (instantaneous dipole - instantaneous dipole), induction (permanent dipole - induced dipole) and orientation (permanent dipole...

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