The essential consequences of polymorphism in the pharmaceutical field
Crystallization and polymorphism - Applications

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The essential consequences of polymorphism in the pharmaceutical field


Crystallization and polymorphism - Applications

Author : Michel BAUER

Publication date: July 10, 2004 | Lire en français

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1. The essential consequences of polymorphism in the pharmaceutical field

Previous articles and have already given a glimpse of the main consequences expected in the pharmaceutical sector.

They mainly concern :

  • dissolution kinetics and, possibly, bioavailability;

  • the manufacturability of the active ingredient and the finished product;

  • the stability of the latter two.

These areas have already been more or less developed, so we'll confine ourselves here to briefly touching on certain aspects.

1.1 Polymorphism / dissolution kinetics and bioavailability

Most drugs are still prescribed orally (tablets, capsules, suspensions,...

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