How do you establish a VTR?
Determining toxicological reference values (TRVs)
Practical sheet REF: FIC1184 V2
How do you establish a VTR?
Determining toxicological reference values (TRVs)

Author : Alain LOMBARD

Publication date: November 10, 2025 | Lire en français

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2. How do you establish a VTR?

Please note

This method of calculating VTRs does not apply to substances without thresholds, such as mutagens, genotoxic carcinogens, and endocrine disruptors.

First, the toxicological profile of the substance must be established and all relevant data collected, then the most relevant and valid studies must be selected (Klimisch), see Determination of Derived No-Effect Levels (DNELs) [FIC 1182] .

Relevant physicochemical data must also be collected by inhalation, in particular the form (gas or particles) and...

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