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Alain LOMBARD: Toxicology and occupational health and safety consultant, Allotoxconsulting
INTRODUCTION
Producers and importers of a chemical substance must define DNELs in the REACh dossier, in order to protect workers, consumers and the general population potentially exposed to the chemical substance.
DNELs must be defined for several types of population: workers, consumers and humans via the environment.
This fact sheet will help you understand how DNELs are calculated and defined, and their impact on the substance to which they apply.
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Determining DNELs
What are DNELs?
Bibliography
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Bibliography
ECETOC: Guidance on Assessment Factors to Derive a DNEL; Technical Report N°110, 2010
ECHA : Guidance on information requirements and chemical safety assessment , Chapter R.8 : Characterisation of dose [concentration]-response for human health, version 2.1, 2012
ECHA : How to prepare toxicological summaries in IUCLID and how to derive...
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