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Archive | REF: FIC1457 V1

Determining DMELs

Author: Alain LOMBARD

Publication date: February 10, 2015 | Lire en français

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2. How do I draw up a DMEL?

The steps are the same as for DNELs, with the exception of the values for non-threshold effects (see Determination of DNELs [FIC 1182] ).

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The first step is to establish the toxicological profile of the substance and collect all relevant data, then select the most relevant and valid studies (Klimisch, see Criteria for determining the rating of a study (Tool

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