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Alain LOMBARD: Toxicology and occupational health and safety consultant, Allotoxconsulting
INTRODUCTION
Producers and importers of a chemical substance must define DMELs in the REACh dossier, in order to protect workers, consumers and the general population potentially exposed to the chemical substance from mutagenic and carcinogenic risks.
DMELs must be defined for several types of population: workers, consumers and humans via the environment.
This fact sheet will help you understand how DMELs are calculated and defined, and their impact on the substance to which they apply.
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Determining DMELs
Bibliography
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Bibliography
ECETOC: Guidance on Assessment Factors to Derive a DNEL; Technical Report N°110, 2010.
ECHA : Guidance on information requirements and chemical safety assessment , Chapter R.8 : Characterisation of dose [concentration]-response for human health, version 2.1, 2012.
ECHA : How to prepare toxicological summaries in IUCLID and how to derive...
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