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Practical sheet | REF: FIC1457 V2

Determining DMEL

Author: Alain LOMBARD

Publication date: November 10, 2025 | Lire en français

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    Overview

    Read this article from a comprehensive knowledge base, updated and supplemented with articles reviewed by scientific committees.

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    AUTHOR

    • Alain LOMBARD: Toxicologist and risk management consultant, Allotoxconsulting, Antibes, France

     INTRODUCTION

    Producers and importers of a chemical substance must define DMELs in the REACh dossier in order to protect workers, consumers, and the general population potentially exposed to the chemical substance from mutagenic and carcinogenic risks.

    DMELs must be defined for several types of populations: workers, consumers, and humans via the environment.

    This fact sheet will help you understand how DMELs are calculated and defined, as well as their impact on the substance to which they apply.

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    EDITIONS

    Other editions of this article are available:

    Feb, 2015 archived version 1 by Alain LOMBARD

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    Determination of DMELs (derived minimal effect levels)
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