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  5. How valid are test results?

Practical sheet | REF: FIC1170 V1

Respiratory irritation, eye irritation, skin irritation: how does the localized action of chemical substances affect the body?

Author: Alain LOMBARD

Publication date: February 10, 2025 | Lire en français

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    8. How valid are test results?

    Irritation and corrosion tests must be carried out in accordance with international guidelines (OECD) and in laboratories working to Good Laboratory Practice (GLP/GLP) and using standardized procedures (SOP) (see Principles of Industrial and Regulatory Toxicology [FIC 1169] ).

    The "in vivo" skin irritation test is performed on albino rabbits, whose skin is not colored and is thinner than that of humans. In addition, chemical substances are applied under a semi-occlusive dressing that keeps the substance in close contact with the skin...

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