Practical sheet | REF: FIC1170 V1

Respiratory irritation, eye irritation, skin irritation: how does the localized action of chemical substances affect the body?

Author: Alain LOMBARD

Publication date: February 10, 2025 | Lire en français

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11. Frequently asked questions

What physico-chemical data do I need to know before starting an irritation/corrosion test?

The essential physico-chemical data to know before starting an irritation/corrosion test are :

  • pH (acidic or basic) to determine the limit of "in vivo" and "in vitro" tests;

  • solubility and stability of the substance in water and fats for penetration through the skin and mucous membranes, as well as respiratory impact (see Toxicology: Routes of penetration and bioavailability in the body (ADME) [FIC 1168]...

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