4. How do endocrine disruptors work?
The activity of low-dose PEs depends on their affinity for nuclear receptors (e.g. tributyltin's high affinity for the PPARγ receptor).
It may also depend on the number of receptors available, or their power of action.
EPs can act on several levels, including :
on hormone synthesis;
on transport ;
on metabolism;
on nuclear receptor (NR) binding;
by disrupting the synthesis of NR ligands;
by altering protein binding to sex hormone binding globulin (SHBG);
by altering binding to the thyroxine transport protein (transthyretrin);
by modifying the clearance of...
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How do endocrine disruptors work?
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Bibliography
Anses (2014a): Assessment of the health risks associated with the presence of endocrine-disrupting and/or reprotoxic substances in consumer products. Collective expertise report, Maisons-Alfort.
Anses (2014b): Caractérisation des dangers et des expositions liés à la présence de substances perturbatrices endocriniennes et/ou reprotoxiques dans les produits de consommation....
Regulations
Règlement (UE) 2020/878 de la Commission du 18 juin 2020 amending Annex II to Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH)....
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