How do chemicals enter the nervous system?
Systemic toxicity: target organs, nervous system
Practical sheet REF: FIC1176 V1
How do chemicals enter the nervous system?
Systemic toxicity: target organs, nervous system

Author : Alain LOMBARD

Publication date: May 10, 2025 | Lire en français

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6. How do chemicals enter the nervous system?

The physico-chemical properties of xenobiotics facilitate their penetration across the brain barrier.

6.1 Size: low molecular weight and small size substances

  • Nanomaterials smaller than 50 nanometers (0.05 microns) reach the brain, particularly the olfactory bulb, by migrating along the olfactory nerves from the olfactory epithelium in the nose, as viruses do.

  • Chemicals with low molecular weight and steric hindrance can pass through membrane channels.

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