Reverse engineering approach

The secondary metabolites most commonly found in marine fungi are polyketides, non-ribosomal peptides and terpenes, which account for around 80% of the natural compounds obtained from these microorganisms . However, these metabolites remain largely inaccessible due to the fact that many biosynthetic pathways are cryptic, i.e. not expressed, or only weakly expressed, under conventional laboratory conditions. Indeed, a bioinformatics analysis of the genome of the species Acremonium chrysogenum, known mainly for its cephalosporin C synthesis, indicates...