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Jasmina Vidic: INRA research engineer - Molecular Virology and Immunology, UR892, INRA Jouy-en-Josas, France
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Édith Pajot-Augy: INRA Research Director - Neurobiology of Olfaction, UR1197, INRA Jouy-en-Josas, France
INTRODUCTION
The diagnosis and monitoring of pathologies, including cancers and infectious diseases, represent major challenges in the healthcare field. New nanobiosensors, whose sensitive elements are olfactory receptors, offer the possibility of developing high-performance, low-cost detection devices, enabling direct, quantitative measurement without markers. This article presents the design principle and biomedical applications of bio-electronic noses. The development of these biosensors is detailed, describing the production of olfactory receptors, methods for their immobilization and odor detection, and the benefits of miniaturization. Finally, examples of recent achievements are provided.
nanomedicine, nanobiosensors, olfactory receptors, odorant detection, nanobiotechnologies, bioelectronic noses
Diagnosis and monitoring of pathologies, including cancers and infectious diseases, represent major challenges in the field of healthcare. New nanobiosensors carring olfactory receptors as sensitive elements provide effective and cheap detection devices allowing a quantitative and direct measurement without any labeling. This article presents the design principle and the biomedical applications of bioelectronic noses. The elaboration of these biosensors is detailed by describing the production of olfactory receptors, the methods for immobilization and for odor detection, as well as the contributions of miniaturization. Finally, examples of recent implementations are provided.
nanomedicine, nanobiosensors, olfactory receptors, odorant detection, nanobiotechnologies, bioelectronic noses
Area: Nanobiotechnologies for health
Degree of technology diffusion: Emergence | Growth | Maturity
Technologies involved: molecular and cellular biology, nanomaterials, surface functionalization, electrochemistry, surface plasmon resonance, nanoelectronics
Applications: medical diagnosis and monitoring
Main French players :
Competitive clusters : –
Centers of expertise: INRA Jouy-en-Josas (Neurobiology of Olfaction), Université Lyon 1 (Institute of Analytical Sciences)
Manufacturers : –
Other international players: University of Barcelona (UB), Spain; Politechnico Milano, Italy; Universita di Salento, Italy; Seoul National University (SNU), South Korea.
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Olfactory nanobiosensors for pathology detection
Context
Bibliography
Websites
Bioelectronic Olfactory Neuron Device http://www.bondproject.org
Directory
Laboratories – Design offices – Schools – Research centers (non-exhaustive list)
Institute for Bioengineering of Catalonia http://www.ibecbarcelona.eu
Institute of Analytical Sciences, Claude Bernard University, Lyon 1 http://isa-lyon.fr
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