8. Glossary – Definitions

ITR; ITRs

ITRs, for Inverted Terminal Repeats, are repeated, inverted sequences found at the ends of certain viral genomes. In the case of AAVs, these sequences form hairpin structures at each end of single-stranded viral DNA. They are involved in genome replication, integration into host cell chromosome 19, and viral encapsidation.

Mode perfusé en culture cellulaire; perfused mode in cell culture

The process of removing culture medium containing metabolized products and replacing it with fresh medium. The cells are kept in place, and the culture volume generally remains the same during the process.

N-glycosylation; N-glycosylation

A series of reactions involving a large number of cellular enzymes, enabling a more or less complex carbohydrate chain to be attached...