4. Insect cell production and industrial developments

Recombinant proteins produced in insect cells are generated during a viral infection; their quantity and quality, as well as the reliability and reproducibility of the production process, are all dependent on the interaction between the virus and the host cell. This interaction depends not only on the genetic characteristics of the virus, but also on the cell's specific physiological parameters. To set up robust, reliable production processes that meet quality standards and regulatory constraints, it is essential to define as precisely as possible the parameters involved in virus-cell interaction.