Becoming after oral administration
Fate of nanomedicine in the human body
Article REF: MED5050 V2
Becoming after oral administration
Fate of nanomedicine in the human body

Author : Frédéric LAGARCE

Publication date: April 10, 2024 | Lire en français

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3. Becoming after oral administration

3.1 Physiology reminders for the oral route

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3.1.1 From the mouth to the stomach

After oral administration, nanomedicines will encounter the oral mucosa and tongue, where they can theoretically be absorbed and pass directly into the bloodstream. They will then pass through the esophagus and arrive in the stomach, which is a fairly aggressive environment for these formulations due to its high acidity (pH between 1.5 and 5 depending on the time of day and concomitant food intake). 

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