Various fluoridation methods
Fluorinations
Article REF: J5670 V1
Various fluoridation methods
Fluorinations

Author : André LANTZ

Publication date: March 10, 1998 | Lire en français

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6. Various fluoridation methods

Apart from the major fluorination processes discussed above, there are many other methods and reagents for introducing a fluorine atom into a molecule. Some of these techniques have found industrial applications (preparation of aromatic fluorinated products by the diazotization method), but most are merely laboratory methods which could nevertheless be of interest for the preparation of particularly complex compounds, used for example in the pharmaceutical field.

6.1 Diazotization method

  • Aromatic derivatives containing one or two fluorine atoms (mono- and difluorobenzenes, monofluorotoluenes, etc.) are prepared industrially by diazotizing the corresponding amines in HF medium and decomposing the resulting diazonium fluorides in situ:...

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