5. Determination of pKa by potentiometry

The potentiometric, or more precisely pH-metric, method is probably the most widely used for determining pK _a . One of the reasons for this is that its use does not require any particular structure of the compound to be studied, such as the presence of a UV-visible absorbing group, an electroactive group, a type of NMR active atom, etc. We have chosen to describe the application of the general methodology already described, as well as a very specific approach to the determination of pK. We have chosen to describe the application of the general methodology already described, as well as a very simplified and straightforward approach to pK values _a .