2. How do you establish a VTR?
This method of calculating VTRs does not apply to substances without thresholds, such as mutagens, genotoxic carcinogens, and endocrine disruptors.
First, the toxicological profile of the substance must be established and all relevant data collected, then the most relevant and valid studies must be selected (Klimisch), see Determination of Derived No-Effect Levels (DNELs)
Relevant physicochemical data must also be collected by inhalation, in particular the form (gas or particles) and...
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How do you establish a VTR?
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Bibliography
Also in our database
Bibliography
ANSES - REPORT, Guide to developing VTRs: criteria and methods (2010).
ECETOC - ECETOC Technical Report 43 Emergency Exposure Indices for Industrial Chemicals (1991).
ECETOC - Technical Report 87, Evaluation of existing Methodologies for setting Acute Exposure Threshold Levels to Derive an European AETL Methodology (2006).
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Websites
This site offers various guides and resources to help you define your emergency response in the event of an accidental release.
In particular, you will find reports on acute toxicity thresholds, including the procedure for determining thresholds...
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