Technological innovations
In vitro and in silico alternatives to animal models in toxicology
Research and innovation REF: RE295 V1
Technological innovations
In vitro and in silico alternatives to animal models in toxicology

Authors : Arnaud TETE, Elias ZGHEIB, Sana AL AWABDH, Louise BENOIT, Kévin BERNAL, Carolina DUARTE HOSPITAL, Lucie LARIGOT, Lorena LOPEZ SUAREZ, Karine ANDREAU, Caroline CHAUVET, Min Ji KIM, Meriem KOUAL, Céline TOMKIEWICZ-RAULET, Xavier COUMOUL, Étienne BLANC, Karine AUDOUZE, Sylvie BORTOLI

Publication date: June 10, 2022 | Lire en français

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5. Technological innovations

Since 2010, technological advances have enabled the development of microfluidic devices that reproduce more "physiological" systems than 2D models and cocultures, for the study of biological systems known as "organ-on-chip" or "body-on-chip". In addition, bioprinting methods enable the construction of 3D tissue models closer to in vivo conditions (figure 14 ).

5.1 Organ-on-chip/body-on-chip

Organ-on-chip" or "body-on-chip" models are miniaturized devices based on a microchip featuring an etched microfluidic system...

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