3. SAS process

3.1 Principle

When the solute is insufficiently soluble in FSC, the latter can be used as an antisolvent. This principle of use is particularly suitable for molecules known for their very low solubility in supercritical CO ₂ , such as sugars, proteins, polymers or metal oxides. The term most commonly used for this family of processes is SAS (for supercritical anti-solvent ). In addition to the compound to be micronized and the FSC, a third compound is involved. This is an organic solvent with at least the following three properties:

• be a good solvent for the compound under study ;

• be compatible with the antisolvent. Ideally, they should even be completely...