Overview
ABSTRACT
The aim of medicinal (or therapeutic) chemistry is to discover and develop new active principles and therefore new medicinal products. This article concisely presents the various techniques used for this purpose in medicinal chemistry. Structure-activity relationships (SAR), precursors and metabolites, research initiated by the knowledge acquired on enzyme receptors and inhibitors, quantitative relationships between structure and activity, stereoisometry, or else the physico-chemical modifications of a medicinal product are many of the elements and notable examples which allow for the illustration of these techniques.
Read this article from a comprehensive knowledge base, updated and supplemented with articles reviewed by scientific committees.
Read the articleAUTHOR
-
Serge KIRKIACHARIAN: Professor Emeritus, Faculty of Pharmacy, Université Paris-Sud
INTRODUCTION
The aim of this text is to give a succinct presentation, illustrated by appropriate examples, of the various techniques used in medicinal chemistry (therapeutic chemistry), with the aim of discovering new drugs. As a general rule, and with the exception of a few special cases, only the international non-proprietary name (INN) corresponding to a given drug is reported. The name(s) of pharmaceutical specialties corresponding to the same INN and/or their structure, preparation methods, pharmacological, pharmacokinetic and therapeutic properties, can be found in various appropriate works [1] to [6].
The Ultimate Scientific and Technical Reference
This article is included in
Drugs and pharmaceuticals
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Medicinal chemistry
Stages of drug discovery
References
Books dealing with the structure and/or preparation, therapeutic indications of drugs or active ingredients:
The Ultimate Scientific and Technical Reference
