Multi-component and organometallic reactions

Given their remarkable potential in organic synthesis, the discovery of new multicomponent reactions is of growing interest. The most classical of these are mainly based on condensation reactions of carbonyl derivatives and the use of reactive compounds such as imines and isonitriles, resulting in limited access to a certain type of nitrogen compounds (peptides, heterocycles via cycloadditions). The use of transition metal-catalyzed reactions has made it possible to achieve greater molecular diversity, thanks to the wide variety of elementary processes they are capable of catalyzing. A suitable catalyst will be able to promote a given reaction to lead efficiently and selectively to the desired product within a reasonable timeframe. This catalyst also offers opportunities to access new molecules that are difficult to access by conventional methods.