6. Conclusion and outlook
The development of pharmacometrics as a scientific discipline, and its gradual diffusion into the life of the drug from development to the patient's bedside, owes much to the work of Lewis Sheiner (see for a list of works and publications). As a statistician, he contributed both to the development of statistical methods and to their implementation in the NONMEM software...
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Conclusion and outlook
Bibliography
Software tools
R Development Core Team 2008 R : A language and environment for statistical computing, [software].
Lixoft SAS 2013 Monolix, [software]. Incuballiance, 86 rue de Paris, 91400 Orsay, France.
Icon Development Solutions 2009 NONMEM, [software]. Icon Development Solutions, Ellicott City, MD, USA.
Foundation for Statistical Computing, Vienna, Austria....
Websites
DDMoRe European Consortium on Disease and Drug Modeling http://www.ddmore.eu/
EMA European Medicines Agency http://www.ema.europa.eu/
FDA Food and Drug Administration http://www.fda.gov
...Events
Conference: American Conference on Pharmacometrix (ACOP) http://www.go-acop.org/
Conference: Population Approach Group in Australia and New Zealand (PAGANZ) http://www.paganz.org
Conference: Population Approach Group in Europe (PAGE). Held annually...
Standards and norms
Food and Drug Administration (FDA). – Guidance for industry: population pharmacokinetics (1999) http://www.fda.gov/downloads/ScienceResearch/SpecialTopics/WomensHealthResearch/UCM133184.pdf
European Medicines Agency (EMEA). – Guideline on reporting the...
Regulations
Food and Drug Administration (FDA), U.S. regulatory agency http://www.fda.gov/
European Medicines Agency (EMEA), European regulatory agency http://www.ema.europa.eu/ema/
French National Agency for the Safety of Medicines and Health Products...
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