3. Estimation methods

We will denote q the set of population parameters to be estimated, which includes in particular the fixed effects μ, the parameters of g such as σ _inter and σ _slope , as well as the parameters describing the distribution $D (Ω) : θ = (μ, Ω, σ_{inter}, σ_{slope})$ ...

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Bibliography

O'REILLY (R.), AGGELER (P.) - Studies on the coumarin anticoagulant drugs. Initiation of warfarin therapy without a loading dose. - Circulation, 38, p. 169-177 (1968).
HOLFORD (N.H.) - Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding...

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