Practical sheet | REF: FIC1413 V1

Validation of the robustness of an analytical method by design of experiments

Author: Morgan GERMA

Publication date: March 10, 2015 | Lire en français

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3. Experimental testing of the plan and collection of responses y

For each experiment in the design, the levels of the various factors are finally converted back into the real unit u i so that the tests can be carried out on a practical level. For example, in the case of the first experiment in the X matrix, the X 1 variable associated with temperature must be adjusted to level -1, which corresponds to a setpoint equal to 24°C ( see figure Area of study of the temperature factor of a CLHPX 1 furnace as part of a robustness study).

Once all the experiments in the design have been carried out in practice, and the corresponding responses y i have been measured, the respective effect of each factor on the response is calculated using the box formula...

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Experimental testing of the plan and collection of responses y