Current situation and developments
BioMolecular Crystallography From phases determination to final structure

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Current situation and developments


BioMolecular Crystallography From phases determination to final structure

Author : Jean CAVARELLI

Publication date: December 10, 2018, Review date: October 23, 2020 | Lire en français

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9. Current situation and developments

We could simplistically say that diffraction data collection (covered in the first article [P 1 110] ) is the last experimental step in biocrystallography. Indeed, if the data are of sufficient quality (crystal diffraction, redundancy, completeness) and if the information to solve the phase problem is present, the rest is made up of steps where human intervention is nowadays reduced to a minimum. Most of these stages have been automated, or "robotized", and are controlled by programs, often organized in pipelines. These pipelines integrate the entire crystallographic process using graphical interfaces, enabling...

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