2. How do you establish a TRV?
This method of calculating TRVs does not apply to non-threshold substances such as mutagens, genotoxic carcinogens and endocrine disruptors.
The first step is to establish the toxicological profile of the substance and collect all relevant data, then select the most relevant and valid studies (Klimisch).
Physico-chemical data relevant to inhalation must also be collected, in particular form (gas or particles) and volatility (boiling point and vapor pressure – PKa) as well as solubility in aqueous and lipid media (partition coefficient – log K O/W).
Next, we need to determine the substance's modes of action (MoA) and identify the effects observed on cells and organs (threshold and non-threshold effects).
Finally, it is necessary to...
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How do you establish a TRV?
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Bibliography
Also in our database
Bibliography
AFSSET (2010): Report, Guide d'élaboration de VTR : critères et méthodes.
ECETOC (1991): ECETOC Technical Report 43Emergency Exposure Indices for Industrial Chemicals.
ECETOC (2006) Technical Report 87, Evaluation of existing Methodologies sor setting Acute Exposure Threshold Levels to Derive an European AETL Methodology.
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