Practical sheet | REF: FIC1168 V1

ADME: circuit of a chemical substance in the body

Author: Alain LOMBARD

Publication date: February 10, 2025 | Lire en français

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1. Absorption: how does a chemical substance enter the body?

1.1 The lungs, the main route by which chemicals enter the body

The lungs are the main route of entry in the following cases:

  • if your substance is a gas;

  • if it's a powdery solid;

  • if it's a liquid with a very high vapor pressure and/or a very low boiling temperature;

  • whether the liquid is in droplet or aerosol form.

The lungs have a very large surface area for exchange with ambient air (alveolar surface area of around 100 to 150 m 2 ).

The volume of air inspired is very important in determining the amount of product that enters the...

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Absorption: how does a chemical substance enter the body?