4. Elimination/excretion: how does our body get rid of chemicals?
4.1 Elimination routes
The physico-chemical properties of the substance and its metabolites determine the route of elimination.
Urine: polar, water-soluble metabolites (benzene and phenol metabolites).
Expired air: all volatile substances (solvents, ethylene, etc.).
Faeces: lipophilic compounds excreted by labile (chlorinated aromatics, etc.) and inert products or undigested substances (kerosene oil, metals, etc.).
Sweat and skin: certain metals (lead, mercury, arsenic, etc.).
The molecular weight of metabolites determines their excretion route.
Low MW...
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Elimination/excretion: how does our body get rid of chemicals?
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Bibliography
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Bibliography
A. Lombard et al. – Techno-economic evaluation of products in the early stages of development. Part 2, pp. 153-281. ISTE Éditions, Ltd London (2024).
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