ADME: circuit of a chemical substance in the body

You make your operators handle chemicals; you want to determine the potential consequences of occupational exposure and understand the toxicity of chemical substances in the short, medium and long term.

This fact sheet will help you understand ADME (Absorption-Distribution-Metabolization-Excretion) or how a chemical substance enters the body (Absorption), how it reaches the various organs (Distribution), how it is processed in the body (Metabolization) and how it is eliminated from the body (Excretion).

This will enable you to deduce the potential risks of exposure to chemical substances in the workplace, and match the means of protection, prevention and individual and collective exposure control available to operators.

• How does a chemical substance enter the body?

• Which organ does it go into?

• What will become of it?