Overview
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Alain LOMBARD: Toxicology and risk management consultant, Allotoxconsulting, Antibes, France
INTRODUCTION
Blood-borne products pass through the liver, where they are transformed into energy or body constituents, or neutralized and excreted.
This fact sheet will help you to understand the impact of xenobiotics on the liver, and to deduce the consequences.
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Systemic toxicity: target organ, liver
What is the liver?
Bibliography
B. Mégarbane, N. Deye, F. Baud: Foie toxique: lésionnels et thérapeutiques, pharmacologiques spécifiques, Réanimation 16, 632-642 (2007).
Lombard et al (2024), part 2 pp. 153-281, Évaluation technico-économique des produits au stade initial du développement, ISTE éditions, Ltd London.
Acronyms/abbreviations
ASAT: ASpartate-AminoTransferase (ASAT)
ALAT: ALanine amino transferase
GGT: Gamma-GlutamylTransferase
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