5. Macrocyclic derivatives
Macrocyclic compounds used in therapeutics are of natural or hemisynthetic origin. The first family, made up of antibiotics, antiparasitics, anticancer agents and immunosuppressants, has a macrocyclic lactone as a common motif (figure 8 ). Most of these compounds are produced by saprophytic bacteria of the genus Streptomyces, generally found in the surface layers of soils.
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Macrocyclic derivatives
Analogues of purine or pyrimidine bases and their derivatives
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